| | | | The main interest of this laboratory is to do research related to the enhancement of drought tolerance in different plant species, improvement of plant resistance against pathogens and using different approaches of molecular breeding to enhance yield in different plant species especially barley and wheat. Furthermore, genetic diversity and population structure of locally collected plants studies are done.
Main Instruments:
· DNA Analyzer (Li-COR)
· Real Time PCR
· High Resolution Gel electrophoresis
· Tissue Lyzer II
· Fluorescent Microscope
· Bio Analyzer
· Micro-Pulser
Services Provided:
· DNA Isolation and Quantification.
· Polymerase Chain Reaction.
· Gene Expression Using Real Time PCR.
· Genetic Diversity Using Li-COR system or High Resolution Gel Electrophoresis.
· Molecular Markers (AFLP, SSR, ISSR, RAPD and SNPs) and its Applications in Plant Breeding Programs.
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| | | | It was established for the purpose of doing plant research which involves growing new plants in a controlled environment. It has three main parts; preparation laboratory, transfer laboratory, growth rooms. Endangered plants growing in Jordan are planted and propagated in the lab. Plant extracts are tested on microbes and cancer cells to study their medicinal effects.
Main Instruments:
· Autoclave
· Laminar flow cabinet
· incubators
Services Provided:
· Training programs for agricultural engineers and students.
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| | | | The main interests of the laboratory are bacterial interaction with its host mainly with plant, microbe-microbe interaction, bacterial resistant mechanism via so-called multidrug efflux pumps. In addition to bacterial protein secretion systems, bacterial population structure and bioactive compounds from microbe, plants and microalgae.
Main Instruments:
· Nanospectrophotometer
· Spectrophotometer
· Gene pulser
· Concentrator
Services Provided :
· Bacterial isolation from different environmental sources.
· Bacterial cultivation and estimation of growth curve.
· Bacterial detection by serological and molecular techniques.
· Bacterial Identification of unknown bacteria by molecular and traditional techniques.
· Bioinformatic analysis by vector NTI software and DNAS-TAR lasergene.
· Genomic DNA isolation and plasmid isolation.
· Gene transformation by electro and chemical poration and conjugation.
· Antagonistic assay of beneficiary bacteria against pathogenic bacteria.
· Antimicrobial activity of medicinal plant extracts.
· Extraction of bioactive compound(s) from bacterial culture.
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| | | | The Laboratory of Pharmaceutical Solutions is interested mainly in the investigation of medicinal plants. The active constituents extracted and identified. Many advanced technical and analytical experiments are performed in this lab as different kinds of extraction, high performance liquid chromatography (HPLC) and gas chromatography (GC). The pharmacological activities of these extracts can be also evaluated.
Main Instruments:
· High performance liquid chromatography (HPLC)
· Gas chromatography (GC).
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| | | | The laboratory has been equipped in the first stage with equipment that were generously donated by Tabuk Pharmaceutical Manufacturing Co. these include manufacturing equipment used in pharmaceutical mixing, granulation, drying, coating and tableting processes as well as testing and analytical equipment. Future collaboration with the pharmaceutical manufacturing companies and funding agencies is expected to improve the research infrastructure and capacity.
The laboratory focuses on developing and testing excipient biocompatible and/or biodegradable materials for pharmaceutical formulation with emphasis on functional excipients working on improving solubility, dissolution rate, permeability and targeted delivery of drug molecules to specific segments of the gastrointestinal tract as well as different tissues and organs in the body. Another aspect of excipient development the laboratory is attempting to address is the development of processing aids. These are excipient materials with improved processability including excellent flow and flow promoting properties and excellent compactability that are highly valuable aid in high speed pharmaceutical manufacturing is another.
In addition, the laboratory's area of research include the development and optimization of manufacturing technologies and the application of statistical optimization techniques in pharmaceutical development in accordance with the "Quality by Design" approach that is adopted by local, regional and international regulatory agencies.
The laboratory provides a significant addition to HMCSR and UJ research capabilities providing researchers and graduate students with facilities and technical support to fulfill their academic mission of research and a link to industrial partners.
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| | | | The Drug Design and Discovery lab runs projects with the basic goal of developing and implementing advanced computer-aided molecular modeling techniques towards the discovery of novel biologically active molecules that can be developed into drugs. Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.
We implement innovative combinations of molecular modeling methodologies by hybridizing pharmcophore modeling with QSAR analysis; molecular docking and 3D-QSAR (e.g., CoMFA and RSA); and in silico screening to identify (discover), validate and optimize new hits to-ward different targets.
We recently run projects that focus mainly on cancer targets and test all the resulted hits tested on the related cancer cells. These hits tested in the Cell Culture lab at the center.
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| | | | Cell culture lab provides an appropriate environment for culturing cancer and normal cells that can be used in testing many synthesized drugs, chemicals, plants extracts, and Nano particles for their cytotoxic effect on both cancer and normal cells as well.
Main Instruments:
· Vertical laminar flow cabinets
· CO2 incubator
· Inverted microscopes
· Liquid nitrogen tanks
Services Provided:
· Basic Tissue Culture Techniques
· Cytotoxicity (proliferation assays)
· DNA fragmentation assay
· Caspases
· Apoptosis assays
· Immunofluorescent assay
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This lab aims to make a positive impact in virology research in Jordan. The lab could establish an experimental platform to study the antiviral effect of novel synthetic compounds and /or medicinal plant extracts against different viruses. We will be able to investigate also how viruses evolve under drug and host selective pressure and how this relates to treatment response and virus progression in infected cells.
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| | | | Material science is an interdisciplinary field applying the properties of matter to various areas of science (chemistry, biology, physics) and engineering. While nanoscience and nanotechnology are the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering
The material science and nanotechnology laboratories at HMCSR incubate research in different projects that have potential in industrial applications such as wastewater treatment and solid waste recycling.
Main Instruments:
· HPLC
· Particle size and zeta potential analyzer
· Ultracentrifuge
· Inductively Coupled Plasma (ICP)
· Freeze dryer
Services Provided:
· Instrumental analysis (Particle size and zeta potential, HPLC, ICP, Freeze-dryer)
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