peripheral arterial disease

Peripheral arterial disease (PAD) is a common manifestation of generalized atherosclerosis and a major cause of morbidity and mortality. Patients with compromised blood flow to the extremities as a consequence of PAD may present with typical ischemia pain, atypical pain, or with no symptoms, and these clinical manifestations of PAD are ameliorated by the development of collateral arteries. Treatment for PAD is dependent on the severity of the symptoms and typically ranges from conservative pharmaceutical management with risk factor modifications to endovascular or open surgical interventions in more severe cases. Up to one third of patients are not candidates to traditional revascularization and may benefit from regenerative medicine.


The purpose of this study is to evaluate the safety, efficacy, and effectiveness of actiplate-3 injections into ischematic limbs of patients with PAD by  testing a product produced at the CTC as well as to generate stem cells capable of making blood vessels to treat these patients. Many of these patients end up having an amputation. We have started with the first few patients and the project will be complete within a year.

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Cell Therapy Center

"The Use of Human Stem Cells for Therapeutic Purposes"